Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging.

@article{Johnson2015DifferentialEO,
  title={Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging.},
  author={Matthew L. Johnson and Brian A. Irving and Ian R Lanza and Mikkel Holm Vendelbo and Adam Richard Konopka and Matthew M. Robinson and Gregory C. Henderson and Katherine A. Klaus and Dawn M. Morse and Carrie Jo Heppelmann and H. R. Bergen and Surendra Dasari and Jill M. Schimke and D Jakaitis and K. Sreekumaran Nair},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2015},
  volume={70 11},
  pages={
          1386-93
        }
}
Acute aerobic exercise increases reactive oxygen species and could potentially damage proteins, but exercise training (ET) enhances mitochondrial respiration irrespective of age. Here, we report a differential impact of ET on protein quality in young and older participants. Using mass spectrometry we measured oxidative damage to skeletal muscle proteins before and after 8 weeks of ET and find that young but not older participants reduced oxidative damage to both total skeletal muscle and… Expand
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