Differential Effect o f Isotype on Efficacy o f Anti-Tumor Necrosis Factor c ~ Chimeric Antibodies in Experimental Septic Shock


Immune complexes containing human gamma (g)l or murine g2a antibodies generate secondary erector mechanisms via Fc receptor binding or complement activation, whereas those containing human g4 or murine gl antibodies generally do not. Therefore, isotype selection of therapeutic antibodies may have important clinical consequences. In a rabbit model of… (More)

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