Differential EDS1 requirement for cell death activities of plant TIR-domain proteins

  title={Differential EDS1 requirement for cell death activities of plant TIR-domain proteins},
  author={Oliver Johanndrees and Erin L. Baggs and Charles Uhlmann and Federica Locci and Henriette L. L{\"a}{\ss}le and Katharina Melkonian and Kiara K{\"a}ufer and Joram A. Dongus and Hirofumi Nakagami and Ksenia V. Krasileva and Jane E. Parker and Dmitry Lapin},
Toll/interleukin-1 Receptor (TIR) domains are integral to immune systems across all domains of life. TIRs exist as single-domain and as larger receptor or adaptor proteins. In plants, TIRs constitute N-terminal domains of nucleotide-binding leucine-rich repeat (NLR) immune receptors. Although TIR-NLR and TIR signaling requires the Enhanced disease susceptibility 1 (EDS1) protein family, TIR domains persist in species that have incomplete or no EDS1 members. To assess whether particular TIR… 
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