Differential Drug Resistance Acquisition in HIV-1 of Subtypes B and C

@article{Soares2007DifferentialDR,
  title={Differential Drug Resistance Acquisition in HIV-1 of Subtypes B and C},
  author={Esmeralda A.J.M. Soares and Andr{\'e} F. A. Santos and Thatiana M. Sousa and Eduardo Sprinz and Ana M.b. Mart{\'i}nez and Jussara Silveira and Amilcar Tanuri and Marcelo Alves Soares},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={55 - 56}
}
BACKGROUND Subtype C is the most prevalent HIV-1 subtype in the world, mainly in countries with the highest HIV prevalence. However, few studies have evaluated the impact of antiretroviral therapy on this subtype. In southern Brazil, the first developing country to offer free and universal treatment, subtypes B and C co-circulate with equal prevalence, allowing for an extensive evaluation of this issue. METHODS AND FINDINGS Viral RNA of 160 HIV-1+ patients was extracted, and the protease and… CONTINUE READING