Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma

@article{Drabovich2013DifferentialDO,
  title={Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma},
  author={Andrei P. Drabovich and Apostolos Dimitromanolakis and Punit Saraon and Antoninus R Soosaipillai and Ihor Batruch and Brendan J Mullen and Keith A. Jarvi and Eleftherios P. Diamandis},
  journal={Science Translational Medicine},
  year={2013},
  volume={5},
  pages={212ra160 - 212ra160}
}
Measurements of seminal plasma proteins ECM1 and TEX101 facilitate the differential diagnosis of azoospermia. To Retrieve, or Not to Retrieve, May No Longer Be the Question Infertility is a very common medical problem, and male partners are responsible for about half the cases. However, male infertility is not a homogeneous disorder, but a collection of diagnoses with different causes and different potential treatments. One type of male infertility, obstructive azoospermia (OA), is caused by… 
Omics in Seminal Plasma: An Effective Strategy for Predicting Sperm Retrieval Outcome in Non-obstructive Azoospermia.
TLDR
The current review aimed to briefly describe genomic, transcriptomic, proteomic, and metabolomic profiles of human seminal plasma in an attempt to introduce potential candidate noninvasive biomarkers for sperm-retrieval success in men with NOA.
Protein markers of spermatogenesis and their potential use in the management of azoospermia
TLDR
Proteins with a potential role as biomarkers of spermatogenesis that could help in the management of non-obstructive and obstructive azoospermia are reviewed.
ESTABLISHING THE TRANSCRIPTOME FOR NON-OBSTRUCTIVE AZOOSPERMIA USING RIBONUCLEIC ACID SEQUENCING, AND IDENTIFICATION OF POTENTIAL BIOMARKERS CHAPTER 6: ESTABLISHING THE TRANSCRIPTOME FOR NON-OBSTRUCTIVE AZOOSPERMIA USING RIBONUCLEIC ACID SEQUENCING, AND IDENTIFICATION OF POTENTIAL BIOMARKERS
  • 2016
There is a need to establish the NOA transcriptome for a better understanding of the molecular mechanisms of the disease: Azoospermia contributes to 20% of infertility cases in men [1]. A patient is
Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility
TLDR
It is recurrently found that micro RNA (miR)-34, miR-122, andmiR-509 are down-regulated in patients with non-obstructive azoospermia (NOA) and oligozoospermia compared with fertile controls and may represent interesting targets whose predictive role in testicular sperm extraction (TESE) or assisted reproductive techniques (ART) outcome deserves further investigation.
Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility
TLDR
The clinical utility of TEX101 ELISA as a test to evaluate vasectomy success, to stratify azoospermia forms, and to better select patients for sperm retrieval is demonstrated.
Semen biomarker TEX101 predicts sperm retrieval success for men with testicular failure
TLDR
Undetectable semen TEX101 is highly predictive of sperm retrieval failure for karyotypically normal men with NOA and is the single strongest non-invasive predictor of sperm retrieved failure reported so far.
Quantitative proteomic analysis of human testis reveals system-wide molecular and cellular pathways associated with non-obstructive azoospermia.
TLDR
Novel candidate proteins identified in this study include key transcription factors, many of which have not previously been shown to be associated with azoospermia, that are highly down-regulated in SCOS and MA patients, thus helping to understand the molecular complexity of spermatogenesis in male infertility.
Azoospermia in male dromedary: Clinical findings, testicular biopsy, serum follicle stimulating hormone and seminal biomarkers.
TLDR
Seminal biomarkers, therefore, might be feasible indicators for identifying azoospermia in the male dromedary camels and the condition of non-obstructive azoOSpermia was seemingly prevalent in the males in the present study.
Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele
TLDR
The state-of-art in seminal plasma proteomics in patients with varicocele is discussed to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome.
An Emerging Role of TEX101 Protein as a Male Infertility Biomarker
TLDR
This review focuses on TEX101, a testicular germ cell-specific protein, one of the most promising male infertility biomarkers, and discusses its role in spermatogenesis and fertilization and summarizes the current knowledge about this new potential biomarker.
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