Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease

@inproceedings{Zeybel2015DifferentialDM,
  title={Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease},
  author={M{\"u}jdat Zeybel and Timothy Hardy and Stuart M. Robinson and Christopher J. Fox and Quentin M Anstee and Thomas Ness and Steven A Masson and John C. Mathers and Jeremy Jules French and Steve A. White and Jelena Mann},
  booktitle={Clinical Epigenetics},
  year={2015}
}
Chronic liver injury can lead to the development of liver fibrosis and cirrhosis but only in a minority of patients. Currently, it is not clear which factors determine progression to fibrosis. We investigated whether DNA\methylation profile as determined by pyrosequencing can distinguish patients with mild from those with advanced/severe fibrosis in non-alcoholic liver disease (NAFLD) and alcoholic liver disease (ALD). To this end, paraffin-embedded liver biopsies were collected from patients… CONTINUE READING
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