Differential DNA Methylation Correlates with Differential Expression of Angiogenic Factors in Human Heart Failure

@inproceedings{Movassagh2010DifferentialDM,
  title={Differential DNA Methylation Correlates with Differential Expression of Angiogenic Factors in Human Heart Failure},
  author={Mehregan Movassagh and Mun-kit Choy and Martin Goddard and Martin R. Bennett and Thomas A. Down and Roger S.-Y. Foo},
  booktitle={PloS one},
  year={2010}
}
Epigenetic mechanisms such as microRNA and histone modification are crucially responsible for dysregulated gene expression in heart failure. In contrast, the role of DNA methylation, another well-characterized epigenetic mark, is unknown. In order to examine whether human cardiomyopathy of different etiologies are connected by a unifying pattern of DNA methylation pattern, we undertook profiling with ischaemic and idiopathic end-stage cardiomyopathic left ventricular (LV) explants from patients… CONTINUE READING

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