Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors

@article{Guillaumond2005DifferentialCO,
  title={Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors},
  author={Fabienne Guillaumond and Hugues Dardente and Vincent Gigu{\`e}re and Nicolas Cermakian},
  journal={Journal of Biological Rhythms},
  year={2005},
  volume={20},
  pages={391 - 403}
}
Circadian rhythms result from feedback loops involving clock genes and their protein products. In mammals, 2 orphan nuclear receptors, REV-ERBα and RORα, play important roles in the transcription of the clock gene Bmal1. The authors now considerably extend these findings with the demonstration that all members of the REV-ERB (α and β) and ROR (α, β, and γ) families repress and activate Bmal1 transcription, respectively. The authors further show that transcription of Bmal1 is the result of… Expand
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TLDR
Examining cell-autonomous circadian oscillations using combined gene knockout and RNA interference demonstrated that REV-ERBα and β are functionally redundant and are required for rhythmic Bmal1 expression, and proposed that the major role of the ROR/REV/Bmal1 loop and its constituents is to control rhythmic transcription of clock output genes. Expand
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TLDR
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TLDR
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