Differential Contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in Vivo Renal Uptake of Uremic Toxins in Rats

@article{Deguchi2005DifferentialCO,
  title={Differential Contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in Vivo Renal Uptake of Uremic Toxins in Rats},
  author={Tsuneo Deguchi and Yousuke Kouno and Tetsuya Terasaki and Akira Takadate and Masaki Otagiri},
  journal={Pharmaceutical Research},
  year={2005},
  volume={22},
  pages={619-627}
}
Evidence suggests that uremic toxins such as hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS), and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) promote the progression of renal failure by damaging tubular cells via rat organic anion transporter 1 (rOat1) and rOat3 on the basolateral membrane of the proximal tubules. The purpose of the current study is to evaluate the in vivo transport mechanism responsible for their renal uptake. We investigated the uremic toxins transport… CONTINUE READING

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