Differential Contribution to Neuroendocrine Tumorigenesis of Parallel Egfr Signaling in Cancer Cells and Pericytes

@inproceedings{NolanStevaux2010DifferentialCT,
  title={Differential Contribution to Neuroendocrine Tumorigenesis of Parallel Egfr Signaling in Cancer Cells and Pericytes},
  author={Olivier Nolan-Stevaux and Morgan C. Truitt and Jessica C. Pahler and Peter R Olson and Cristina D. Guinto and David C. Lee and Douglas Hanahan},
  booktitle={Genes & cancer},
  year={2010}
}
Factors associated with tumor sensitivity to epidermal growth factor receptor (EGFR) inhibitors in the context of wild-type EGFR remain elusive. This study investigates the mechanistic basis of responsiveness to EGFR inhibitors in the RIP1-Tag2 (RT2) mouse model of pancreatic neuroendocrine tumorigenesis (PNET). Upon treatment of RT2 mice with EGFR inhibitors, PNET tumors harboring wild-type, nonamplified alleles of Egfr grow at a markedly reduced rate and display a significant increase in… CONTINUE READING

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