Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages

@article{Omahony2008DifferentialCA,
  title={Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages},
  author={Deborah O'mahony and Uyenvy Pham and R. Subramanyam Iyer and Thomas Richard Hawn and W Conrad Liles},
  journal={International Journal of Medical Sciences},
  year={2008},
  volume={5},
  pages={1 - 8}
}
Human Toll-like receptors (TLRs) comprise a family of proteins that recognizes pathogen-associated molecular patterns (PAMPs) and initiates host innate immune responses. Neutrophils, monocytes, and macrophages are critical cellular components of the human innate immune system. Proinflammatory cytokines, such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interferon-gamma (IFN-gamma… CONTINUE READING

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Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Proinflammatory cytokines , such as granulocyte colony - stimulating factor ( G - CSF ) , granulocyte - macrophage colony - stimulating factor ( GM - CSF ) , macrophage colony - stimulating factor ( M - CSF ) , and interferon - gamma ( IFN - gamma ) , have been shown to up - regulate microbicidal activity in these effector cells of innate immunity .
Using quantitative realtime rt - PCR technology , we examined constitutive expression of TLR2 , TLR4 , TLR5 , and TLR9 mRNA and the effects of G - CSF , GM - CSF , M - CSF , and IFN - gamma on TLR mRNA expression in purified populations of normal human neutrophils , monocytes , and monocyte - derived macrophages .
Using quantitative realtime rt - PCR technology , we examined constitutive expression of TLR2 , TLR4 , TLR5 , and TLR9 mRNA and the effects of G - CSF , GM - CSF , M - CSF , and IFN - gamma on TLR mRNA expression in purified populations of normal human neutrophils , monocytes , and monocyte - derived macrophages .
Human Toll - like receptors ( TLRs ) comprise a family of proteins that recognizes pathogen - associated molecular patterns ( PAMPs ) and initiates host innate immune responses .
Human Toll - like receptors ( TLRs ) comprise a family of proteins that recognizes pathogen - associated molecular patterns ( PAMPs ) and initiates host innate immune responses .
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