Differential Compartmentalization and Distinct Functions of GABAB Receptor Variants

@article{Vigot2006DifferentialCA,
  title={Differential Compartmentalization and Distinct Functions of GABAB Receptor Variants},
  author={R{\'e}jan Vigot and Samuel Barbieri and Hans Br{\"a}uner-Osborne and Rostislav Turecek and Ryuichi Shigemoto and Yan-Ping Zhang and Rafael Luj{\'a}n and Laura Helen Jacobson and Barbara Biermann and J. -M. Fritschy and Claire-Marie Vacher and Matthias M{\"u}ller and Gilles Sansig and Nicole Guetg and John F Cryan and Klemens Kaupmann and Martin Gassmann and Thomas G. Oertner and Bernhard Bettler},
  journal={Neuron},
  year={2006},
  volume={50},
  pages={589-601}
}
GABAB receptors are the G protein-coupled receptors for the main inhibitory neurotransmitter in the brain, gamma-aminobutyric acid (GABA). Molecular diversity in the GABAB system arises from the GABAB1a and GABAB1b subunit isoforms that solely differ in their ectodomains by a pair of sushi repeats that is unique to GABAB1a. Using a combined genetic, physiological, and morphological approach, we now demonstrate that GABAB1 isoforms localize to distinct synaptic sites and convey separate… CONTINUE READING
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