Differential CRX and OTX2 expression in human retina and retinoblastoma.

@article{Glubrecht2009DifferentialCA,
  title={Differential CRX and OTX2 expression in human retina and retinoblastoma.},
  author={Darryl D. Glubrecht and Jihyeon Kim and Laurie Russell and J Stephen Bamforth and Roseline Godbout},
  journal={Journal of neurochemistry},
  year={2009},
  volume={111 1},
  pages={
          250-63
        }
}
  • Darryl D. Glubrecht, Jihyeon Kim, +2 authors Roseline Godbout
  • Published 2009
  • Medicine, Biology
  • Journal of neurochemistry
  • The histogenesis of retinoblastoma tumors remains controversial, with the cell-of-origin variably proposed to be an uncommitted retinal progenitor cell, a bipotent committed cell, or a cell committed to a specific lineage. [...] Key Result We show that CRX and OTX2 have distinct expression profiles in the developing human retina, with CRX first expressed in proliferating cells and cells committed to the bipolar lineage, and OTX2 first appearing in the photoreceptor lineage.Expand Abstract

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