Differential CRX and OTX2 expression in human retina and retinoblastoma.

  title={Differential CRX and OTX2 expression in human retina and retinoblastoma.},
  author={Darryl D. Glubrecht and Ji-Hyeon Kim and Laurie Russell and J. Stephen Bamforth and Roseline Godbout},
  journal={Journal of neurochemistry},
  volume={111 1},
The histogenesis of retinoblastoma tumors remains controversial, with the cell-of-origin variably proposed to be an uncommitted retinal progenitor cell, a bipotent committed cell, or a cell committed to a specific lineage. Here, we examine the expression of two members of the orthodenticle family implicated in photoreceptor and bipolar cell differentiation, cone-rod homeobox, CRX, and orthodenticle homeobox 2, OTX2, in normal human retina, retinoblastoma cell lines and retinoblastoma tumors. We… CONTINUE READING
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