Differential Behavioral Effects of Peripheral and Systemic Morphine and Naloxone in a Rat Model of Repeated Acute Inflammation

@article{Perrot2001DifferentialBE,
  title={Differential Behavioral Effects of Peripheral and Systemic Morphine and Naloxone in a Rat Model of Repeated Acute Inflammation},
  author={Serge Perrot and Gis{\'e}le Guilbaud and Val{\'e}rie Kayser},
  journal={Anesthesiology},
  year={2001},
  volume={94},
  pages={870-875}
}
Background It has been reported that opioid antinociceptive effects are enhanced in animal models of inflammation, but it remains unclear whether this sensitization to morphine is related to predominant central or peripheral increased effects. Methods The authors compared the behavioral effects of intraplantar and intravenous morphine and naloxone in a rat model of repeated acute carrageenan-induced inflammation in which enhanced responses to noxious stimuli result from sensitization in… 

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