Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

@article{Soria2010DifferentialAO,
  title={Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder},
  author={Virginia Soria and {\`E}rika Mart{\'i}nez-Amor{\'o}s and Ge{\`o}rgia Escaram{\'i}s and Joaqu{\'i}n Valero and Rosario P{\'e}rez-Egea and Cecilia Lopes Garcia and Alfonso Guti{\'e}rrez-Zotes and Dolors Puigdemont and M{\'o}nica Bay{\'e}s and J. M. Crespo and L Martorell and Elisabet Vilella and Antonio Labad and Julio Vallejo and V{\'i}ctor P{\'e}rez and Jos{\'e} M. Mench{\'o}n and Xavier Estivill and M{\'o}nica Gratac{\'o}s and Mikel Urretavizcaya},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={1279-1289}
}
Disruptions in circadian rhythms have been described in mood disorders (MD), but the involvement of genetic variation in genes pertaining to the molecular circadian machinery in the susceptibility to MD has not been conclusively determined. We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335… CONTINUE READING
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