Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers

  title={Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers},
  author={Natalie Hudson and Michael B. Powner and Mosharraf H. Sarker and Thomas Burgoyne and Matthew S Campbell and Zoe K. Ockrim and Roberta Martinelli and Clare E Futter and Maria B Grant and Paul A. Fraser and David T. Shima and John Greenwood and Patric Turowski},
  booktitle={Developmental cell},
The vascular endothelium operates in a highly polarized environment, but to date there has been little exploration of apicobasal polarization of its signaling. We show that VEGF-A, histamine, IGFBP3, and LPA trigger unequal endothelial responses when acting from the circulation or the parenchymal side at blood-neural barriers. For VEGF-A, highly polarized receptor distribution contributed to distinct signaling patterns: VEGFR2, which was found to be predominantly abluminal, mediated increased… CONTINUE READING
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