Differential Agonist Inhibition Identifies Multiple Epibatidine Binding Sites in Mouse Brain 1

The binding of [H]epibatidine, an alkaloid isolated from the skin of an Ecuadorean tree frog, was measured both in brain regions dissected from mouse brain and in tissue sections. Binding to each of 12 brain areas was saturable, but apparently monophasic; no indication of multiple binding sites was obtained. However, inhibition of epibatidine binding by… CONTINUE READING