Differential Agglutination of Normal and Sensitized Sheep Erythrocytes by Sera of Patients with Rheumatoid Arthritis

  title={Differential Agglutination of Normal and Sensitized Sheep Erythrocytes by Sera of Patients with Rheumatoid Arthritis},
  author={Harry M. Rose and Charles Ragan and E Pearce and Miriam Olmstead Lipman},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={1 - 6}
Summary A differential sheep cell agglutination test is described wherein the agglutination titers of human serum for normal and sensitized sheep erythrocytes are compared. High differential titers have been found to occur almost solely with the sera of patients suffering from active rheumatoid arthritis. Some of the features of this serological phenomenon are pointed out, together with its possible practical applications. 

Red Blood Cells Sensitized by Incomplete Rabbit Antibodies as a Reagent for Detecting the Rheumatoid Factor

A new procedure for the detection of the rheumatoid factor was described, which consisted of blood group G + rabbit erythrocytes sensitized by incomplete anti-G serum of rabbit origin.

The Agglutinating Factor for Sensitized Sheep Erythrocytes in Serum and Joint Fluid from Rheumatoid Arthritis Patients

Since February, 1949, the present authors have been studying the agglutinating factor for sensitized sheep cells by an absorption method, which has not hitherto been described in detail.

Differential Sheep-Cell Agglutination Test in Rheumatoid Arthritis *

The results of the sheep-cell agglutination test performed on sera of 164 patients and 13 normal adult males are presented, which correlate the presence of a raised titre with greater severity and increased duration of the disease.

Cold Precipitable Haemagglutinating Factor in Serum from patients with Rheumatoid Arthritis

The agglutination test with sensitized sheep erythrocytes, first described by Meyer and rediscovered Rose and into the test in question correlation haemagglutinating and rheumatoid arthritis

The differential sheep cell agglutination test in arthritis.

While the serologic properties of blood of patients with rheumatoid arthritis have been studied extensively, no test of diagnostic value has, as yet, been devised, and it is considered that the height of the differential titer reflected the clinical activity of the disease.

The latex agglutination and inhibition reactions; clinical experience in the diagnosis of rheumatoid arthritis.

It has become clear that serums from rheumatoid patients contain a factor (or factors) that is either absent or present in minimal amounts in the serums of normal persons.


The serum of patients with rheumatoid arthritis contains a factor which causes agglutination of sensitized particulate bodies, and this phenomenon leads to inflammation in the immune system.

Studies on the rheumatoid and related serum factors. I. Autoimmunization of rabbits with gamma globulin.

The puzzling observation that the sera of patients with rheumatoid arthritis agglutinated sheep red cells sensitized by subagglutinating doses of rabbit anti-sheep hemolysin are made has not been completely elucidated.

The sensitized sheep cell agglutination reaction in rheumatoid arthritis.

  • J. Sharp
  • Medicine
    Annals of internal medicine
  • 1956
Excerpt Marked enhancement of various agglutination reactions by non-immune serum was occasionally reported during the early decades of the present century, but the possible clinical significance o...