Differential Activation of Nuclear Receptors by Perfluorinated Fatty Acid Analogs and Natural Fatty Acids: A Comparison of Human, Mouse, and Rat Peroxisome Proliferator-Activated Receptor-α, -β, and -γ, Liver X Receptor-β, and Retinoid X Receptor-α

@inproceedings{Heuvel2006DifferentialAO,
  title={Differential Activation of Nuclear Receptors by Perfluorinated Fatty Acid Analogs and Natural Fatty Acids: A Comparison of Human, Mouse, and Rat Peroxisome Proliferator-Activated Receptor-α, -β, and -γ, Liver X Receptor-β, and Retinoid X Receptor-α},
  author={John P. Vanden Heuvel and Jerry Todd Thompson and S. Randall Frame and Peter John Gillies},
  year={2006}
}
Administration of ammonium salts of perfluorooctanoate (PFOA) to rats results in peroxisome proliferation and benign liver tumors, events associated with activation of the nuclear receptor (NR) peroxisome proliferator-activated receptor-a (PPARa). Due to its fatty acid structure, PFOA may activate other NRs, such as PPARb, PPARg, liver X receptor (LXR), or retinoid X receptor (RXR). In this study, the activation of human, mouse, and rat PPARa, PPARb, PPARg, LXRb, and RXRa by PFOA (including its… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 120 CITATIONS

FILTER CITATIONS BY YEAR

2006
2018

CITATION STATISTICS

  • 17 Highly Influenced Citations

  • Averaged 10 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Perfluorinated fatty acids for the treatment of diabetes , obesity , cardiovascular disease or as anti - tumour agents

  • C. R. Elcombe, C. R. Wolf
  • 2004
1 Excerpt

Perfluorinated fatty acids for the treatment of diabetes, obesity, cardiovascular disease or as anti-tumour agents

  • C. R. Elcombe, C. R. Wolf
  • UK Patent GB 2392386
  • 2004
1 Excerpt

Similar Papers

Loading similar papers…