Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs.

@article{Zimmerman2012DifferentialC,
  title={Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs.},
  author={Brandon Zimmerman and Alexandre Beautrait and Benjamin Aguila and Ricardo Charles and Emanuel Escher and Audrey Claing and Michel Bouvier and St{\'e}phane A Laporte},
  journal={Science signaling},
  year={2012},
  volume={5 221},
  pages={ra33}
}
The angiotensin type 1 receptor (AT1R) and its octapeptide ligand, angiotensin II (AngII), engage multiple downstream signaling pathways, including those mediated by heterotrimeric guanosine triphosphate-binding proteins (G proteins) and those mediated by β-arrestin. Here, we examined AT1R-mediated Gα(q) and β-arrestin signaling with multiple AngII analogs bearing substitutions at position 8, which is critical for binding to the AT1R and its activation of G proteins. Using assays that… CONTINUE READING

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