Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development.

@article{Chavarra2007DifferentialAM,
  title={Differential, age-dependent MEK-ERK and PI3K-Akt activation by insulin acting as a survival factor during embryonic retinal development.},
  author={Teresa Chavarr{\'i}a and Ana Isabel Valenciano and R. Bernades Mayordomo and Joaquim Egea and Joan X Comella and Finn Hallb{\"o}{\"o}k and Flora de Pablo and Enrique J de la Rosa},
  journal={Developmental neurobiology},
  year={2007},
  volume={67 13},
  pages={1777-88}
}
Programmed cell death is a genuine developmental process of the nervous system, affecting not only projecting neurons but also proliferative neuroepithelial cells and young neuroblasts. The embryonic chick retina has been employed to correlate in vivo and in vitro studies on cell death regulation. We characterize here the role of two major signaling pathways, PI3K-Akt and MEK-ERK, in controlled retinal organotypic cultures from embryonic day 5 (E5) and E9, when cell death preferentially affects… CONTINUE READING

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