Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress.

@article{Wang2003DifferentTO,
  title={Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress.},
  author={H C Wang and Han-Chieh Wu and Chien-Fu Chen and Nelson Fausto and Huan-Yao Lei and I Fan Su},
  journal={The American journal of pathology},
  year={2003},
  volume={163 6},
  pages={2441-9}
}
Ground glass hepatocyte (GGH) represents a histological hallmark of chronic hepatitis B virus infection and contains surface antigens in the endoplasmic reticulum (ER). Several types of GGHs are recognized at different hepatitis B virus replicative stages. The recent identification of pre-S mutants from GGHs encourages us to investigate whether different GGHs may harbor specific mutants and exhibit differential biological activities. In this study, we applied laser capture microdissection to… CONTINUE READING
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