Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala

@article{Killcross1997DifferentTO,
  title={Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala},
  author={Simon Killcross and Trevor William Robbins and Barry J. Everitt},
  journal={Nature},
  year={1997},
  volume={388},
  pages={377-380}
}
The amygdala has long been thought to be involved in emotional behaviour, and its role in anxiety and conditioned fear has been highlighted. Individual amygdaloid nuclei have been shown to project to various cortical and subcortical regions implicated in affective processing. Here we show that some of these nuclei have separate roles in distinct mechanisms underlying conditioned fear responses. Rats with lesions of the central nucleus exhibited reduction in the suppression of behaviour elicited… 
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References

SHOWING 1-10 OF 52 REFERENCES
The role of the amygdala in fear and anxiety.
  • M. Davis
  • Psychology, Medicine
    Annual review of neuroscience
  • 1992
TLDR
The idea that the amygdala, and its many efferent projections, may represent a central fear system involved in both the expression and acquisition of conditioned fear is summarized.
The amygdala and emotion
TLDR
The use of animal models has progressively defined the circuitry for these functions within the amygdala and its interconnections with other brain systems, including pathways through which the amygdala modulates memory and regulates attention.
Anxiety and the Amygdala: Pharmacological and Anatomical Analysis of the Fear-Potentiated Startle Paradigm
Publisher Summary This chapter describes the fear-potentiated startle paradigm and the advantages it provides for the pharmacological and neuroanatomical analyses of fear conditioning. It also…
Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues
TLDR
A double dissociation of the effects of amygdala and hippocampal damage on fear conditioning to explicit and contextual cues is suggested.
Impaired auditory recognition of fear and anger following bilateral amygdala lesions
TLDR
A further investigation is reported of one of these rare cases, a woman who has impaired perception of the intonation patterns that are essential to the perception of vocal affect, despite normal hearing, which shows that the amygdala's role in the recognition of certain emotions is not confined to vision, which is consistent with its being involved in the appraisal of danger and the emotion of fear.
Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradient.
TLDR
Results reveal that neurons in the BLA have an enduring role in the expression of conditional fear.
The basolateral amygdala-ventral striatal system and conditioned place preference: Further evidence of limbic-striatal interactions underlying reward-related processes
TLDR
Data provide further support for the hypothesis that the basolateral amygdala and ventral striatum are important parts of a neural system subserving stimulus-reward associations.
Facial Emotion Recognition after Bilateral Amygdala Damage: Differentially Severe Impairment of Fear
Although the amygdala is widely believed to have a role in the recognition of emotion, a central issue concerns whether it is involved in the recognition of all emotions or whether it is more…
The basolateral amygdala regulates sensorimotor gating of acoustic startle in the rat
TLDR
The results of the present study suggest that the basolateral amygdala regulates sensorimotor gating by mechanisms that are independent of central dopamine hyperactivity.
The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.
Anatomical Organization of the Primate Amygdaloid Complex Distribution of Monoamines Within the Amygdala Neurophysiology and Functions of the Primate Amygdala Emotional Neurophysiology of the Human…
...
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