Different trajectories of parallel evolution during viral adaptation.

@article{Wichman1999DifferentTO,
  title={Different trajectories of parallel evolution during viral adaptation.},
  author={H. Wichman and M. Badgett and L. Scott and C. M. Boulianne and J. Bull},
  journal={Science},
  year={1999},
  volume={285 5426},
  pages={
          422-4
        }
}
The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal. Experimental evolution of two bacteriophage lines under strong selection led to over a dozen nucleotide changes genomewide in each replicate. At least 96 percent of the amino acid substitutions appeared to be adaptive, and half the changes in one line also occurred in the other. However, the order of these changes differed between replicates, and… Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Exceptional convergent evolution in a virus.
  • 314
  • PDF
Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations.
  • R. Lenski, M. Travisano
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1994
  • 865
  • PDF
Adaptive protein evolution at the Adh locus in Drosophila
  • 3,072
  • PDF
Episodic adaptive evolution of primate lysozymes
  • 447
  • PDF
Stochastic processes strongly influence HIV-1 evolution during suboptimal protease-inhibitor therapy.
  • 156
  • PDF
Molecular evolution
  • D. Labie
  • Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 1975
  • 1,880
...
1
2
3
4
...