Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA.

@article{Bourtchouladze1998DifferentTP,
  title={Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA.},
  author={Rusiko Bourtchouladze and Ted Abel and Nancy Berman and Ruthanna Gordon and Kyle A. B. Lapidus and Eric R Kandel},
  journal={Learning & memory},
  year={1998},
  volume={5 4-5},
  pages={365-74}
}
We have used a combined genetic and pharmacological approach to define the time course of the requirement for protein kinase A (PKA) and protein synthesis in long-term memory for contextual fear conditioning in mice. The time course of amnesia in transgenic mice that express R(AB) and have genetically reduced PKA activity in the hippocampus parallels that observed both in mice treated with inhibitors of PKA and mice treated with inhibitors of protein synthesis. This PKA- and protein synthesis… CONTINUE READING
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