Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs

@article{Cummings2016DifferentTP,
  title={Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs},
  author={Ryan J. Cummings and Gaetan Barbet and Gerold Bongers and Boris M. Hartmann and Kyle Gettler and Luciana Muniz and Glaucia C Furtado and Judy H Cho and Sergio A Lira and J Magarian Blander},
  journal={Nature},
  year={2016},
  volume={539},
  pages={565-569}
}
Recognition and removal of apoptotic cells by professional phagocytes, including dendritic cells and macrophages, preserves immune self-tolerance and prevents chronic inflammation and autoimmune pathologies. The diverse array of phagocytes that reside within different tissues, combined with the necessarily prompt nature of apoptotic cell clearance, makes it difficult to study this process in situ. The full spectrum of functions executed by tissue-resident phagocytes in response to homeostatic… CONTINUE READING

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