Different tissue distribution of paclitaxel with intravenous and intraperitoneal administration.

@article{Soma2009DifferentTD,
  title={Different tissue distribution of paclitaxel with intravenous and intraperitoneal administration.},
  author={Daisuke Soma and Joji Kitayama and Hironori Ishigami and Shoichi Kaisaki and Hirokazu Nagawa},
  journal={The Journal of surgical research},
  year={2009},
  volume={155 1},
  pages={
          142-6
        }
}
PURPOSE Paclitaxel is considered to be suitable for disseminated cancer in the peritoneal cavity because of its high molecular weight and lipophilic characteristics. However, the difference in pharmacokinetics of paclitaxel after intraperitoneal (i.p.) and intravenous (i.v.) administration is not fully defined. Here, we investigated the tissue concentration of paclitaxel in various organs at various time points after i.p. or i.v. administration. METHODS Paclitaxel (5 mg/kg) was administrated… CONTINUE READING

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