Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation.

@article{Carbone2003DifferentSO,
  title={Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation.},
  author={Michele Carbone and Carol Burck and Monica A Rdzanek and Jennifer J Rudzinski and Rochelle M Cutrone and Maurizio Bocchetta},
  journal={Cancer research},
  year={2003},
  volume={63 19},
  pages={6125-9}
}
SV40 has been associated with mesothelioma development. The possible role of the closely related human polyomaviruses JC virus (JCV) and BK virus (BKV) in mesothelioma remained unclear. We found that JCV did not infect human mesothelial cells. BKV and SV40 infected mesothelial cells, expressed viral oncoproteins, and caused similar alterations of key cell regulatory genes. BKV replicated faster than SV40 and caused mesothelial cell lysis, not cellular transformation. SV40 did not lyse… CONTINUE READING

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Immunization safety review; SV40 contamination of polio vaccine and cancer

  • Michele Carbone, Carol Burck, Monica Rdzanek
  • Institute of Medicine of the National Academies,
  • 2002

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