Different substance P receptors are found on mucosal epithelial cells and submucous neurons of the guinea-pig small intestine

@article{Keast1985DifferentSP,
  title={Different substance P receptors are found on mucosal epithelial cells and submucous neurons of the guinea-pig small intestine},
  author={Janet R. Keast and John Barton Furness and Marcello Costa},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1985},
  volume={329},
  pages={382-387}
}
The action of substance P (SP) on mucosal ion transport has been investigated in the guinea-pig small intestine. Segments of intestine were dissected free of external muscle and myenteric plexus and mounted in Ussing chambers. Short-circuit current (I sc) was measured as an indication of net ion transport across the tissue. SP (>10−10 M) added to the submucosal side of the tissue caused a transient increase in I sc. Tetrodotoxin (TTX, 10−7 M) decreased the maximum SP response to 11% of the… CONTINUE READING
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Antagonist discrimination between neuronal and muscular receptors for substance P in the guinea-pig ileum

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1 Excerpt

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