Different structural requirements for functional ion pore transplantation suggest different gating mechanisms of NMDA and kainate receptors.

@article{Villmann2008DifferentSR,
  title={Different structural requirements for functional ion pore transplantation suggest different gating mechanisms of NMDA and kainate receptors.},
  author={Carmen Villmann and Jutta Hoffmann and Markus Werner and Sabine Kott and Nathalie Strutz-Seebohm and Tanja Nilsson and Michael Hollmann},
  journal={Journal of neurochemistry},
  year={2008},
  volume={107 2},
  pages={453-65}
}
Although considerable progress has been made in characterizing the physiological function of the high-affinity kainate (KA) receptor subunits KA1 and KA2, no homomeric ion channel function has been shown. An ion channel transplantation approach was employed in this study to directly test if homomerically expressed KA1 and KA2 pore domains are capable of… CONTINUE READING