Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9.

@article{Reyes2015DifferentSO,
  title={Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9.},
  author={Raquel Reyes and Alicia Monjas and Mar{\'i}a Y{\'a}{\~n}ez-M{\'o} and Beatriz Carde{\~n}es and Giulia Morlino and Alvaro Gilsanz and Yesenia Machado-Pineda and Esther M. Lafuente and Peter N Monk and Francisco S{\'a}nchez-Madrid and Carlos Caba{\~n}as},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1853 10 Pt A},
  pages={2464-80}
}
The tetraspanin CD9 has been shown to interact with different members of the β1 and β3 subfamilies of integrins, regulating through these interactions cell adhesion, migration and signaling. Based on confocal microscopy co-localization and on co-immunoprecipitation results, we report here that CD9 associates with the β2 integrin LFA-1 in different types of leukocytes including T, B and monocytic cells. This association is resistant to stringent solubilization conditions which, together with… CONTINUE READING