Different specificities of cloned T cells assessed by in vitro proliferation assays and by the ability to mediate skin graft rejection in vivo.

@article{Lynch1987DifferentSO,
  title={Different specificities of cloned T cells assessed by in vitro proliferation assays and by the ability to mediate skin graft rejection in vivo.},
  author={David H. Lynch and D J Weiland and Steven A Rosenberg and R J Hodes},
  journal={Transplantation},
  year={1987},
  volume={43 3},
  pages={408-11}
}
The experiments presented here have compared the specificities of T cell clones as determined by in vitro proliferative responses and their specificities as reflected by their ability to mediate skin graft rejection in vivo. Two proliferative T cell clones with distinct in vitro specificities were evaluated for their ability to mediate rejection of skin grafts from C57BL/10 Scn nu/nu mice. Clone 14.11 (L3T4+, Lyt2-) was specifically stimulated to proliferate in vitro by I-Ad determinants, while… CONTINUE READING