Different signal transduction pathways are involved during human sperm capacitation induced by biological and pharmacological agents.

@article{Thundathil2002DifferentST,
  title={Different signal transduction pathways are involved during human sperm capacitation induced by biological and pharmacological agents.},
  author={Jacob Thundathil and Eve de Lamirande and Claude Gagnon},
  journal={Molecular human reproduction},
  year={2002},
  volume={8 9},
  pages={
          811-6
        }
}
Human sperm capacitation involves complex signal transduction mechanisms during which double phosphorylation of the threonine-glutamine-tyrosine motif (P-Thr-Glu-Tyr-P) occurs in some sperm proteins. The objective of this study was to investigate the regulation of this process. Fetal cord serum ultrafiltrate (FCSu), follicular fluid ultrafiltrate (FFu), progesterone and a combination of N(6),2'-O-dibutyryl cAMP (dbcAMP; cell permeant analogue of cAMP) and 3-isobutyl-1-methylxanthine (IBMX… CONTINUE READING

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