Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.

  title={Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.},
  author={Laura M. Hurley},
  journal={Journal of neurophysiology},
  volume={96 5},
  • L. Hurley
  • Published 1 November 2006
  • Biology, Psychology
  • Journal of neurophysiology
The neuromodulator serotonin has a complex set of effects on the auditory responses of neurons within the inferior colliculus (IC), a midbrain auditory nucleus that integrates a wide range of inputs from auditory and nonauditory sources. To determine whether activation of different types of serotonin receptors is a source of the variability in serotonergic effects, four selective agonists of serotonin receptors in the serotonin (5-HT) 1 and 5-HT2 families were iontophoretically applied to IC… 

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Activation of the serotonin 1A receptor alters the temporal characteristics of auditory responses in the inferior colliculus

  • L. Hurley
  • Biology, Psychology
    Brain Research
  • 2007

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From behavioral context to receptors: serotonergic modulatory pathways in the IC

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The results suggest that serotonin, whose release varies with behavioral state, functionally reconfigures the circuitry of the IC and may modulate the perception of acoustic signals under different behavioral states.

Serotonin Shifts First-Spike Latencies of Inferior Colliculus Neurons

The results support the general conclusion that changes in latency are an important part of the neuromodulatory repertoire of serotonin within the auditory system and show that serotonin can change latency either in conjunction with broad changes in other aspects of neuronal excitability or in highly specific ways.

Differential Actions of Serotonin, Mediated by 5-HT1Band 5-HT2C Receptors, on GABA-Mediated Synaptic Input to Rat Substantia Nigra Pars Reticulata Neurons In Vitro

Serotonin can both depolarize and disinhibit SNr neurons via 5-HT2C and5-HT1B receptors, respectively, but excitation may be limited by GABA released from axon collaterals, while spontaneous tetrodotoxin-sensitive GABAA synaptic currents were increased in frequency but reduced in frequency by serotonin.

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The present neuroanatomic and neurochemical findings support behavioral and neurophysiologic findings that the serotonergic system may modulate central auditory processing.

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It is indicated that serotonergic overactivation can disrupt auditory and visual sensorimotor gating as measured using sound and light prepulse inhibition in rats, and a potential role of excessive 5-HT activity as a contributing factor to disrupted sensory gating processes seen in schizophrenia and possibly other neuropsychiatric disorders is supported.