Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.

@article{Hurley2006DifferentSR,
  title={Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.},
  author={Laura M. Hurley},
  journal={Journal of neurophysiology},
  year={2006},
  volume={96 5},
  pages={
          2177-88
        }
}
  • L. Hurley
  • Published 1 November 2006
  • Biology, Psychology
  • Journal of neurophysiology
The neuromodulator serotonin has a complex set of effects on the auditory responses of neurons within the inferior colliculus (IC), a midbrain auditory nucleus that integrates a wide range of inputs from auditory and nonauditory sources. To determine whether activation of different types of serotonin receptors is a source of the variability in serotonergic effects, four selective agonists of serotonin receptors in the serotonin (5-HT) 1 and 5-HT2 families were iontophoretically applied to IC… 

Figures from this paper

Activation of the serotonin 1A receptor alters the temporal characteristics of auditory responses in the inferior colliculus

  • L. Hurley
  • Biology, Psychology
    Brain Research
  • 2007

Serotonin 1B receptor modulates frequency response curves and spectral integration in the inferior colliculus by reducing GABAergic inhibition.

In vivo extracellular recording and iontophoresis of the selective 5-HT1B agonist CP93129 were used to characterize inhibition within and surrounding frequency response curves using two-tone protocols to indirectly measure inhibition as a decrease in spikes relative to an excitatory tone alone, consistent with the reduction of GABAA-mediated inhibition by 5- HT1B receptors in the IC.

Modulation of auditory brainstem responses by serotonin and specific serotonin receptors

From behavioral context to receptors: serotonergic modulatory pathways in the IC

A broad model of serotonin receptors as a link between behavioral context and reconfiguration of circuitry in the IC is supported, and the resulting possibility that plasticity at the level of specific receptor types could alter the relationship between context and circuit function is considered.

Context-dependent modulation of auditory processing by serotonin

5-HT1A Receptors Alter Temporal Responses to Broadband Vocalizations in the Mouse Inferior Colliculus Through Response Suppression

The influence of the serotonergic system on the responses of neurons in a mouse auditory midbrain nucleus, the inferior colliculus (IC), to vocal signals is measured to contribute to the differential auditory processing of BBVs in different behavioral subcontexts.

5‐HT1A and 5‐HT1B receptors differentially modulate rate and timing of auditory responses in the mouse inferior colliculus

The results suggest that cooperative interactions between 5‐HT1A and 5‐ HT1B receptors shape auditory encoding in the inferior colliculus, and that the effects of neuromodulators within sensory systems may depend nonlinearly on the specific profile of receptors that are activated.

Acoustic trauma triggers upregulation of serotonin receptor genes

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