Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes.

@article{Braun2000DifferentST,
  title={Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes.},
  author={Uschi Braun and Klaus Rajewsky and Roberta Pelanda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 13},
  pages={
          7429-34
        }
}
Ig knock-in mice have been used to study the relative contribution of receptor selection versus clonal selection in the control of autoreactive B cells. The anti-MHC class I 3-83Ig knock-in (3-83Igi) mice manifest extensive receptor editing in the presence of H-2(b). However, receptor editing is also observed on the H-2(d) background, although reactivity toward this antigen is below detection and its presence does not affect the generation of 3-83Ig(+) mature B cells in classical 3-83Ig… CONTINUE READING

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