Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors.

@article{Stoop1997DifferentST,
  title={Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors.},
  author={Reinout Stoop and Annmarie Surprenant and R Alan North},
  journal={Journal of neurophysiology},
  year={1997},
  volume={78 4},
  pages={1837-40}
}
The effect of changing extracellular pH was studied on the currents induced by ATP or alphabeta-methylene-ATP in HEK293 cells transfected with different P2X receptor subunits. In cells expressing P2X1, P2X3, or P2X4 receptors, the effect of ATP was decreased by acidification. In cells expressing P2X2 receptors, acidification increased the ATP-induced current; this effect was also seen in cells expressing heteromeric P2X2 and P2X3 receptors. At P2X2 receptors, acidification caused a leftward… CONTINUE READING
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