Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene.

@article{Goldmann1991DifferentSF,
  title={Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene.},
  author={Wilfred Goldmann and Nora E. Hunter and Gary Benson and James D. Foster and Jayne Hope},
  journal={The Journal of general virology},
  year={1991},
  volume={72 ( Pt 10)},
  pages={
          2411-7
        }
}
The incubation period of scrapie in sheep is controlled by the Sip gene which has two alleles (sA and pA). Following experimental challenge with SSBP/1 scrapie, a short incubation period is conferred by the partially dominant sA allele. Restriction fragment length polymorphisms of the scrapie-associated fibril protein (PrP) gene are associated with the Sip alleles. By sequencing the protein coding region of the PrP gene in Cheviot sheep selected for differing Sip genotypes, we have found four… CONTINUE READING

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