Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH-17 cells

@inproceedings{Pepper2010DifferentRO,
  title={Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH-17 cells},
  author={Marion Pepper and Jonathan L. Linehan and Antonio J. Pag{\'a}n and Traci Zell and Thamotharampillai Dileepan and Paul Patrick Cleary and Marc K Jenkins},
  booktitle={Nature Immunology},
  year={2010}
}
We used a sensitive method based on tetramers of peptide and major histocompatibility complex II (pMHCII) to determine whether CD4+ memory T cells resemble the T helper type 1 (TH1) and interleukin 17 (IL-17)-producing T helper (TH17) subsets described in vitro. Intravenous or intranasal infection with Listeria monocytogenes induced pMHCII-specific CD4+ naive T cells to proliferate and produce effector cells, about 10% of which resembled TH1 or TH17 cells, respectively. TH1 cells were also… CONTINUE READING
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