Different roles of the IGF‐I Ec peptide (MGF) and mature IGF‐I in myoblast proliferation and differentiation

@article{Yang2002DifferentRO,
  title={Different roles of the IGF‐I Ec peptide (MGF) and mature IGF‐I in myoblast proliferation and differentiation},
  author={Shi-yu Yang and G. Goldspink},
  journal={FEBS Letters},
  year={2002},
  volume={522}
}
The physiological function of a recently cloned splice variant of insulin‐like growth factor‐I (IGF‐I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF‐I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF‐I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and… Expand
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