Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells.

@article{Lech2007DifferentRO,
  title={Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells.},
  author={Maciej Lech and Cecilia Garlanda and Alberto Mantovani and Carsten J Kirschning and Detlef Schloendorff and Hans-Joachim Anders},
  journal={Kidney international},
  year={2007},
  volume={72 2},
  pages={182-92}
}
Toll-like receptors (TLRs) exist on both myeloid and intrinsic renal cells contributing to the initiation of innate immunity during renal infection with uropathogenic Escherichia coli. Toll-interleukin 1 receptor (IL-1R) (TIR)8/SIGIRR is an orphan receptor of the TLR/IL-1R family, which suppresses TLR signaling of immune cells and is highly expressed in the kidney. Lack of TIR8/SIGIRR is associated with enhanced renal chemokine signaling upon exposure to lipopolysaccharide (LPS). This was… CONTINUE READING