Different roles of S100P overexpression in intrahepatic cholangiocarcinoma; Carcinogenesis of perihilar type and aggressive behavior of peripheral type Running title: S100P expression in intrahepatic cholangiocarcinoma


S100P is expressed in several kinds of malignant tumors. Intracellular S100P interacts with ezrin, and extracellular S100P activates the receptor for advanced glycation end-products (RAGE). However, little is known about the biological significance of S100P and related protein in cholangiocarcinoma. Biliary intraepithelial neoplasia (BilIN) is a precursor… (More)