Different roles for type A and type B monoamine oxidase in regulating synaptic dopamine at D-1 and D-2 receptors associated with adenosine-3′,5′-cyclic monophosphate (cyclic AMP) formation

@article{Liccione1988DifferentRF,
  title={Different roles for type A and type B monoamine oxidase in regulating synaptic dopamine at D-1 and D-2 receptors associated with adenosine-3′,5′-cyclic monophosphate (cyclic AMP) formation},
  author={John J. Liccione and Albert J. Azzaro},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1988},
  volume={337},
  pages={151-158}
}
The roles of multiple forms of monoamine oxidase (MAO) in regulating the synaptic concentration of dopamine, in the vicinity of dopamine receptors associated with cyclic AMP formation, was examined in striatal slices of the rat. d-Amphetamine (0.1 μmol/l to 20 μmol/l) caused a concentration-related increase in cyclic AMP formation, which correlated (in superfusion experiments) with the release of endogenously-formed dopamine. In the presence of (−)sulpiride (50 pmol/l), cyclic AMP formation was… CONTINUE READING