Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection.

@article{Campbell2005DifferentRF,
  title={Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection.},
  author={Lacey G. Campbell and Sabarinathan Ramachandran and Wei Liu and J. Michael Shipley and Shigeyoshi Itohara and J. G. Rogers and Nader Moazami and Robert M. Senior and Andr{\'e}s David Ram{\'i}rez Jaramillo},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2005},
  volume={5 3},
  pages={517-28}
}
Recent studies have shown an increased expression of several matrix metalloproteinases (MMP) during cardiac, renal and pulmonary allograft rejection. To further define the roles of MMP-2 and MMP-9 in the pathogenesis of cardiac allograft rejection, BALB/c cardiac allografts were transplanted into MMP-2-deficient (-/-) and MMP-9-/- mice. Allografts rejected by wild-type mice revealed a significant increase in MMP-2 and MMP-9 expression. MMP-2-deficiency significantly prolonged allograft survival… CONTINUE READING

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