Different roles for L3T4+ and Lyt 2+ T cell subsets in the control of an acute herpes simplex virus infection of the skin and nervous system.

Abstract

Rat monoclonal antibodies were used to deplete selectively Lyt 2 (cytotoxic) and L3T4 (helper) T cell populations in vivo. These antibodies produced greater than 95% depletion of the respective T cell subset as determined by fluorescent antibody and cytofluorographic analyses. Antibody-treated mice were infected in the ear pinna with herpes simplex virus… (More)

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@article{Nash1987DifferentRF, title={Different roles for L3T4+ and Lyt 2+ T cell subsets in the control of an acute herpes simplex virus infection of the skin and nervous system.}, author={Anthony Nash and Anula K. Jayasuriya and James Phelan and Stephen Paul Cobbold and Herman Waldmann and Terence D. Prospero}, journal={The Journal of general virology}, year={1987}, volume={68 ( Pt 3)}, pages={825-33} }