Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection.

@article{Almeida2001DifferentRO,
  title={Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection.},
  author={Angeles Almeida and Julia Valeriano de Almeida and Juan P Bola{\~n}os and Salvador Moncada},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 26},
  pages={15294-9}
}
It was recently proposed that in Jurkat cells, after inhibition of respiration by NO, glycolytically generated ATP plays a critical role in preventing the collapse of mitochondrial membrane potential (Deltapsi(m)) and thus apoptotic cell death. We have investigated this observation further in primary cultures of rat cortical neurons and astrocytes-cell types that differ greatly in their glycolytic capacity. Continuous and significant ( approximately 85%) inhibition of respiration by NO (1.4… CONTINUE READING
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