Different regions in activation function-1 of the human estrogen receptor required for antiestrogen- and estradiol-dependent transcription activation.

@article{McInerney1996DifferentRI,
  title={Different regions in activation function-1 of the human estrogen receptor required for antiestrogen- and estradiol-dependent transcription activation.},
  author={Eileen M. McInerney and Benita S Katzenellenbogen},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 39},
  pages={24172-8}
}
The human estrogen receptor (ER) is a ligand-inducible transcription factor that contains two transcriptional activation functions, one located in the NH2-terminal region of the protein (AF-1) and the second in the COOH-terminal region (AF-2). Antiestrogens, such as trans-hydroxytamoxifen (TOT), have partial agonistic activity in certain cell types, and studies have implied that this agonism is AF-1-dependent. We have made progressive NH2-terminal and other segment deletions and ligations in… CONTINUE READING
56 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Similar Papers

Loading similar papers…