Different reactivity and structure of the prestenotic and poststenotic aorta in human coarctation. Implications for baroreceptor function.

@article{Sehested1982DifferentRA,
  title={Different reactivity and structure of the prestenotic and poststenotic aorta in human coarctation. Implications for baroreceptor function.},
  author={Jens Sehested and Ulrik Thorngren Baandrup and Erich O. Mikkelsen},
  journal={Circulation},
  year={1982},
  volume={65 6},
  pages={1060-5}
}
In eight humans with coarctation, fresh aortic tissue was examined pharmacodynamically. In four of these patients, and in 12 additional patients, the aorta above and below the coarctation was studied morphologically and compared with eight control aortas. By in vitro stimulation with potassium (127 mM), noradrenaline (18 microM), and prostaglandin F2 alpha (28 microM), postcoarctational aortic ring preparations showed a significantly greater contractility than precoarctational rings (p less… CONTINUE READING