Different properties of three isoforms (alpha, beta, and gamma) of transcription factor AP-2 in the expression of human keratinocyte genes.

@article{Oyama2002DifferentPO,
  title={Different properties of three isoforms (alpha, beta, and gamma) of transcription factor AP-2 in the expression of human keratinocyte genes.},
  author={Noritaka Oyama and Hidetoshi Takahashi and Michiko Tojo and Keiji Iwatsuki and Hajime Iizuka and Koichiro Nakamura and Yoshimi Homma and Fumio Kaneko},
  journal={Archives of dermatological research},
  year={2002},
  volume={294 6},
  pages={
          273-80
        }
}
The transcription factor AP-2/promoter system is essential for gene expression associated with ectodermal development, particularly in the neural crest and skin. Three AP-2 isoforms, alpha, beta, and gamma, exhibit a highly homologous structure, but their functions are considered to be different. Here, we report on the role of each AP-2 isoform in complex keratinocyte biology including proliferation, differentiation, and carcinogenesis. The expression of AP-2 was investigated… CONTINUE READING

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