Different programs of activation-induced cell death are triggered in mature activated CTL by immunogenic and partially agonistic peptide ligands.

@article{Wei2001DifferentPO,
  title={Different programs of activation-induced cell death are triggered in mature activated CTL by immunogenic and partially agonistic peptide ligands.},
  author={Cheng-hong Wei and H. Yagita and Maria G Masucci and Victor Levitsky},
  journal={Journal of immunology},
  year={2001},
  volume={166 2},
  pages={989-95}
}
Activation-induced cell death (AICD) of mature T cells plays an important role in the control of immune homeostasis and peripheral tolerance. TNFRs and Fas have been implicated in the induction of AICD. However, these molecules were shown to be dispensable, at least in some experimental systems, for downsizing of Ag-induced T cell expansions and development of tolerance in vivo. The conditions of T cell activation leading to T cell deletion in a death receptor-independent manner are not well… CONTINUE READING

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