Different platelet specificities of heparin-dependent platelet aggregating factors in heparin-associated immune thrombocytopenia.

@article{Pfueller1986DifferentPS,
  title={Different platelet specificities of heparin-dependent platelet aggregating factors in heparin-associated immune thrombocytopenia.},
  author={S L Pfueller and Robert O. David},
  journal={British journal of haematology},
  year={1986},
  volume={64 1},
  pages={149-59}
}
Delayed onset heparin-associated thrombocytopenia (HAT) is thought to be a result of formation of antiplatelet antibodies which cause platelet aggregation in the presence of heparin. Platelet aggregation in response to serum from patients with HAT has been studied in platelet-rich plasma (PRP) from a panel of normal blood donors. Heparin-dependent aggregation with any HAT serum occurred in PRP from only some donors. PRP from the non-responding donors did, however, aggregate in the presence of… CONTINUE READING